In collaboration with the Bollen lab in our department, we have shown that the abundance of RepoMan, an important phosphatase scaffold, is regulated by the same mechanisms that control the kinase Aurora B. Using experimental and numerical work, we demonstrate that the co–up-regulation of RepoMan and Aurora B is associated with tumor aggressiveness, but it also exposes a vulnerable target for therapeutic intervention. Congratulations to Maria Giulia of the Bollen lab who did all the experimental work and Jan for his numerical contributions! For more information, see our article in MBoC.
