Cell cycle oscillations driven by two interlinked bistable switches
Negative feedback is at the heart of cell cycle oscillations: active cyclin B-Cdk1 activates the Anaphase-Promoting Complex-Cyclosome, which triggers the degradation of cyclin B. In the early embryos of the frog Xenopus laevis, such cell cycle oscillations occur fast and periodically. In this paper by Pedro and Dani, we built several cell cycle oscillator models …
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