How do nuclei control mitotic waves in an import-diffusion model?

In this work, Felix extended the modeling work he did for our 2020 eLife paper in which we showed that nuclei control the spatial origin of mitotic waves. He analyzed a model where nuclei periodically import and export cell cycle regulators, leading to a redistribution of such regulator in the cytoplasm. We show that when the cell cycle period depends on the local concentration of regulators, the model exhibits mitotic waves. Congratulations Felix! Read more here.