Congratulations to Junbin of the Bollen lab who just published his research in Molecular Cell. In collaboration with our lab, Junbin showed that there exists a transient phosphorylation signal (BUB1-T461ph) that plays a crucial role in correctly activating the mitotic checkpoint. This novel biochemical timer activates the checkpoint independently of the microtubule-kinetochore attachment status, and we show that disrupting this BUB1 timer holds therapeutic potential by targeting cancer cells. The paper was featured on the KU Leuven news.
